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Downregulation of the Hsp90 System Causes Defects in Muscle Cells of Caenorhabditis Elegans

28 Sept 2011

Abstract excerpt

The ATP-dependent molecular chaperone Hsp90 is required for the activation of a variety of client proteins involved in various cellular processes. Despite the abundance of known client proteins, functions of Hsp90 in the organismal context are not fully explored. In Caenorhabditis elegans, Hsp90 (DAF-21) has been implicated in the regulation of the stress-resistant dauer state, in chemosensing and in gonad...

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PMID: 21980476
DOI: 10.1371/journal.pone.0025485

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