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Article

A computational approach identifies two regions of Hepatitis C Virus E1 protein as interacting domains involved in viral fusion process.

BMC structural biology - 29 Jul 2009

Bruni Roberto, Costantino Angela, Tritarelli Elena, Marcantonio Cinzia, Ciccozzi Massimo, Rapicetta Maria, El Sawaf Gamal, Giuliani Alessandro, Ciccaglione Anna Rita

Abstract excerpt

BACKGROUND: The E1 protein of Hepatitis C Virus (HCV) can be dissected into two distinct hydrophobic regions: a central domain containing an hypothetical fusion peptide (FP), and a C-terminal domain (CT) comprising two segments, a pre-anchor and a trans-membrane (TM) region. In the currently accepted model of the viral fusion process, the FP and the TM regions are considered to be closely juxtaposed in the...

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Identifiers

PMID: 19640267
DOI: 10.1186/1472-6807-9-48
PMCID: PMC2732612

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Source receipt: pubmed, retrieved 7 Sept 2026.

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