Retrospective analysis of children with α-1 antitrypsin deficiency.

doi:10.1097/MEG.0000000000001108

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Article

Retrospective analysis of children with α-1 antitrypsin deficiency.

European journal of gastroenterology & hepatology - 1 Jul 2018

Comba Atakan, Demirbaş Fatma, Çaltepe Gönül, Eren Esra, Kalayci Ayhan G

Abstract excerpt

BACKGROUND: α-1 Antitrypsin (AAT) deficiency is the most frequently occurring genetic liver disorder. The association among classical α-1 antitrypsin deficiency (AATD), chronic liver disease, and cirrhosis is common in adult patients but rare in children. AIM: To assess the clinical characteristics of children with AATD and to compare symptoms between homozygous and heterozygous children. MATERIALS AND METHODS:...

Topics

Adolescent
Age Factors
Biopsy
Child
Child, Preschool
Cholestasis
Delayed Diagnosis
Female
Genetic Predisposition to Disease
Hepatitis, Chronic
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Infant

Liver Cirrhosis

Liver Diseases

Male

Mutation

Source

Open in PubMed

Identifiers

PMID: 29505478
DOI: 10.1097/MEG.0000000000001108

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