Article
Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression.
Biological psychiatry - 1 Mar 2002
Cubells Joseph F, Price Lawrence H, Meyers Barnett S, Anderson George M, Zabetian Cyrus P, Alexopoulos George S, Nelson J Craig, Sanacora Gerard, Kirwin Paul, Carpenter Linda, Malison Robert T, Gelernter Joel
Abstract excerpt
BACKGROUND: Plasma activity of dopamine beta-hydroxylase (DbetaH), the enzyme that converts dopamine to norepinephrine, is reportedly lower in patients with unipolar major depression with psychotic features (UDPF) than in those with nonpsychotic unipolar major depression (UD). Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that...
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