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Article

Deficiency of Atg6 impairs beneficial effect of metformin on intestinal stem cell aging in Drosophila.

Biochemical and biophysical research communications - 25 Mar 2018

Na Hyun-Jin, Pyo Jung-Hoon, Jeon Ho-Jun, Park Joung-Sun, Chung Hae-Young, Yoo Mi-Ae

Abstract excerpt

Age-related changes of adult stem cell are crucial for tissue aging and age-related diseases. Thus, clarifying mechanisms to prevent adult stem cell aging is indispensable for healthy aging. Metformin, a drug for type 2 diabetes, has been highlighted for its anti-aging and anti-cancer effect. In Drosophila intestinal stem cell (ISC), we previously reported the inhibitory effect of metformin on age-related...

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PMID: 29496445
DOI: 10.1016/j.bbrc.2018.02.191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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