Article

Autophagy is dispensable in germline stem cells but is required in the cap cells for their maintenance in the Drosophila ovarian niche

2024-10-22

Abstract excerpt

Autophagy is a cytoprotective mechanism responsible for the maintenance and long-term survival of various cell types, including stem cells. However, its role in the Germline stem cell (GSC)-niche, including its effects on GSCs and niche cells, remains unexplored. We demonstrate that autophagy flux in female Drosophila GSCs is low and dependent on the core autophagy gene, Atg5 . However, the maintenance of Atg5-/...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b92e17c5-19fb-5587-a3ac-eb426918cf1b
DOI: 10.1101/2024.10.21.619512

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autophagy is dispensable in germline stem cells but is required in the cap cells for their maintenance in the Drosophila ovarian nicheDOI 10.1101/2024.10.21.619512Read

Autophagy slows the aging of Germline stem cells in <i>Drosophila</i> through modulation of E-cadherinSemantic proximity Read

Autophagy in adult stem cell homeostasis, aging, and disease therapySemantic proximity Read

Autophagy maintains stem cells and intestinal homeostasis in DrosophilaSemantic proximity Read

Autophagy in stem cellsSemantic proximity Read

Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and DifferentiationSemantic proximity Read

Roles of autophagy in controlling stem cell identity: a perspective of self-renewal and differentiationSemantic proximity Read

Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and agingSemantic proximity Read

Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.Semantic proximity Read

Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female miceSemantic proximity Read

Autophagy in stem cell agingSemantic proximity Read

Autophagy is required for self-renewal and differentiation of adult human stem cellsSemantic proximity Read

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenanceSemantic proximity Read