Article
Use of next-generation sequencing in the CHAT study (acute HCV in HIV): effect of baseline resistance-associated NS3 variants on treatment failure.
HIV clinical trials - 1 Apr 2018
Jagjit Singh Gurmit Kaur, Kaye Steve, Abbott James C, Boesecke Christoph, Rockstroh Juergen, McClure Myra O, Nelson Mark
Abstract excerpt
Background The epidemic of acute HCV infection among HIV-infected men who have sex with men (MSM) is ongoing. Transmission of drug-resistant variants (DRVs) after HCV treatment failure could pose a major threat to the effectiveness of future therapies. We determined the baseline prevalence of pre-existing DRVs in the HCV NS3 protease gene and their effects on the addition of telaprevir (TVR) to standard pegylated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.