Article
Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort.
Antiviral therapy - 1 Jan 2018
Halfon Philippe, Scholtès Caroline, Izopet Jacques, Larrat Sylvie, Trimoulet Pascale, Zoulim Fabien, Alric Laurent, Métivier Sophie, Leroy Vincent, Ouzan Denis, de Lédinghen Victor, Mohamed Sofiane, Pénaranda Guillaume, Khiri Hacène, Thélu Marie-Ange, Plauzolles Anne, Chiche Laurent, Bourlière Marc, Abravanel Florence
Abstract excerpt
BACKGROUND: Recent data have suggested that failure to achieve sustained virological response with direct-acting antiviral therapy is usually due to relapse and is primarily associated with the emergence of resistance-associated substitutions. The aim of this study was to investigate the prevalence and characterization of non-structural-5A resistance-associated substitutions in patients infected with HCV...
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