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Dynamics of Imprinted DNA Methylation and Gene Transcription for Imprinting Establishment in Mouse Oocytes in Relation to Culture Duration Variability1

10 Oct 2013

Abstract excerpt

Several studies have linked assisted reproductive technologies to aberrant imprinting. We previously showed that 12-day in vitro follicle culture supports normal imprinting establishment in mouse oocytes. The aim of the present study was to assess whether shortened in vitro follicle growth (8 days of culture compared with 12 days, as a model for human in vitro maturation) or preovulatory intrafollicular oocyte...

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PMID: 24108304
DOI: 10.1095/biolreprod.113.111641

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