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Article

Genomic imprints as a model for the analysis of epigenetic stability during assisted reproductive technologies

7 Sept 2012

Abstract excerpt

Gamete and early embryo development are important stages when genome-scale epigenetic transitions are orchestrated. The apparent lack of remodeling of differential imprinted DNA methylation during preimplantation development has lead to the argument that epigenetic disruption by assisted reproductive technologies (ARTs) is restricted to imprinted genes. We contend that aberrant imprinted methylation arising from...

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PMID: 22956517
DOI: 10.1530/rep-12-0237

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