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Article

Aberrant DNA methylation of imprinted loci in superovulated oocytes

21 Aug 2006

Abstract excerpt

BACKGROUND: There is an increased incidence of rare imprinting disorders associated with assisted reproduction technologies (ARTs). The sex-specific epigenetic modifications that are imposed during gametogenesis act as a primary imprint to distinguish maternal and paternal alleles. The most likely candidate for the gametic mark is DNA methylation. However, the timing of DNA methylation acquisition in adult...

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Share to Assisted Reproductive Technology and Twin Pregnancy
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PMID: 16923747
DOI: 10.1093/humrep/del316

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