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Article

Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression.

Behavioural brain research - 1 Nov 2018

Lim Patrick H, Wert Stephanie L, Tunc-Ozcan Elif, Marr Robert, Ferreira Adriana, Redei Eva E

Abstract excerpt

Aging and major depressive disorder are risk factors for dementia, including Alzheimer's Disease (AD), but the mechanism(s) linking depression and dementia are not known. Both AD and depression show greater prevalence in women. We began to investigate this connection using females of the genetic model of depression, the inbred Wistar Kyoto More Immobile (WMI) rat. These rats consistently display depression-like...

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PMID: 29490235
DOI: 10.1016/j.bbr.2018.02.030

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