Article
The association between cancer family history and ovarian cancer risk in BRCA1/2 mutation carriers: can it be explained by the mutation position?
European journal of human genetics : EJHG - 1 Jun 2018
Teixeira Natalia, van der Hout Annemieke, Oosterwijk Jan C, Vos Janet R, Devilee Peter, van Engelen Klaartje, Meijers-Heijboer Hanne, van der Luijt Rob B, Kriege Mieke, Mensenkamp Arjen R, Rookus Matti A, van Roozendaal Kees E, Mourits Marian J E, de Bock Geertruida H
Abstract excerpt
This observational study aimed to investigate whether the reported association between family history (FH) of breast cancer (BC) or ovarian cancer (OC) and OC risks in BRCA1/2 mutation carriers can be explained by mutation position on the gene. In total, 3310 female BRCA1/2 mutation carriers participating in a nationwide prospective cohort (Hereditary Breast and Ovarian Cancer in the Netherlands) were included....
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