Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.

doi:10.1093/jnci/90.23.1824

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Article

Effect of BRCA1 and BRCA2 on the association between breast cancer risk and family history.

Journal of the National Cancer Institute - 2 Dec 1998

Claus E B, Schildkraut J, Iversen E S, Berry D, Parmigiani G

Abstract excerpt

BACKGROUND: The discovery of BRCA1 and BRCA2 has led to a reassessment of the association between family history of breast/ovarian cancer and breast cancer risk after controlling for carrier status for mutations in the BRCA1 and BRCA2 genes. We examined whether family history of breast cancer rem...

Topics

Adult
Breast Neoplasms
Case-Control Studies
Female
Genes, BRCA1
Genes, Tumor Suppressor
Heterozygote
Humans
Logistic Models
Middle Aged
Mutation
Odds Ratio
Predictive Value of Tests
Risk
Risk Factors

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