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Article

Dysregulation of RNF213 promotes cerebral hypoperfusion.

Scientific reports - 26 Feb 2018

Morimoto Takaaki, Enmi Jun-Ichiro, Hattori Yorito, Iguchi Satoshi, Saito Satoshi, Harada Kouji H, Okuda Hiroko, Mineharu Yohei, Takagi Yasushi, Youssefian Shohab, Iida Hidehiro, Miyamoto Susumu, Ihara Masafumi, Kobayashi Hatasu, Koizumi Akio

Abstract excerpt

RNF213 is a susceptibility gene for moyamoya disease, yet its exact functions remain unclear. To evaluate the role of RNF213 in adaptation of cerebral blood flow (CBF) under cerebral hypoperfusion, we performed bilateral common carotid artery stenosis surgery using external microcoils on Rnf213 knockout (KO) and vascular endothelial cell-specific Rnf213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice....

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Identifiers

PMID: 29483617
DOI: 10.1038/s41598-018-22064-8
PMCID: PMC5827518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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