Article
BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2017
Barras David, Missiaglia Edoardo, Wirapati Pratyaksha, Sieber Oliver M, Jorissen Robert N, Love Chris, Molloy Peter L, Jones Ian T, McLaughlin Stephen, Gibbs Peter, Guinney Justin, Simon Iris M, Roth Arnaud D, Bosman Fred T, Tejpar Sabine, Delorenzi Mauro
Abstract excerpt
PURPOSE: Mutation of BRAF at the valine 600 residue occurs in approximately 10% of colorectal cancers, a group with particularly poor prognosis. The response of BRAF mutant colorectal cancer to recent targeted strategies such as anti-BRAF or combinations with MEK and EGFR inhibitors remains limited and highly heterogeneous within BRAF V600E cohorts. There is clearly an unmet need in understanding the biology of...
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