Article
Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure.
Circulation research - 11 May 2018
Rainer Peter P, Dong Peihong, Sorge Matteo, Fert-Bober Justyna, Holewinski Ronald J, Wang Yuchuan, Foss Catherine A, An Steven S, Baracca Alessandra, Solaini Giancarlo, Glabe Charles G, Pomper Martin G, Van Eyk Jennifer E, Tomaselli Gordon F, Paolocci Nazareno, Agnetti Giulio
Abstract excerpt
RATIONALE: Disrupted proteostasis is one major pathological trait that heart failure (HF) shares with other organ proteinopathies, such as Alzheimer and Parkinson diseases. Yet, differently from the latter, whether and how cardiac preamyloid oligomers (PAOs) develop in acquired forms of HF is unclear. OBJECTIVE: We previously reported a rise in monophosphorylated, aggregate-prone desmin in canine and human HF. We...
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