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Article

Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy.

The Journal of biological chemistry - 7 Oct 2011

Diguet Nicolas, Mallat Youssef, Ladouce Romain, Clodic Gilles, Prola Alexandre, Tritsch Eva, Blanc Jocelyne, Larcher Jean-Christophe, Delcayre Claude, Samuel Jane-Lise, Friguet Bertrand, Bolbach Gérard, Li Zhenlin, Mericskay Mathias

Abstract excerpt

Alterations in the balance of cytoskeleton as well as energetic proteins are involved in the cardiac remodeling occurring in dilated cardiomyopathy (DCM). We used two-dimensional DIGE proteomics as a discovery approach to identify key molecular changes taking place in a temporally controlled model of DCM triggered by cardiomyocyte-specific serum response factor (SRF) knock-out in mice. We identified muscle...

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Share to alpha-Crystallin B Chain
Share to Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electrophoresis, Gel, Two-Dimensional

Share to Glycation End Products, Advanced

Share to Heart Ventricles

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Source

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Identifiers

PMID: 21768101
DOI: 10.1074/jbc.M111.252395
PMCID: PMC3186397

Genes

SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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