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Article

Desmin filaments and cardiac disease: establishing causality.

Journal of cardiac failure - 1 Dec 2002

Wang Xuejun, Osinska Hanna, Gerdes A Martin, Robbins Jeffrey

Abstract excerpt

BACKGROUND: Gene targeting studies indicate that desmin is not required for embryonic myogenesis and heart formation but is essential for maintaining the structural and functional integrity of myocytes. Desmin-null mouse hearts developed hypertrophy and dilatation. However, the expression of desmin is very often upregulated rather than downregulated in many cardiac diseases. Altered distribution of desmin protein...

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Identifiers

PMID: 12555134
DOI: 10.1054/jcaf.2002.129279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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