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Article

Desmin modifications associate with amyloid-like oligomers deposition in heart failure.

Cardiovascular research - 1 Apr 2014

Agnetti Giulio, Halperin Victoria L, Kirk Jonathan A, Chakir Khalid, Guo Yurong, Lund Linda, Nicolini Francesco, Gherli Tiziano, Guarnieri Carlo, Caldarera Claudio M, Tomaselli Gordon F, Kass David A, Van Eyk Jennifer E

Abstract excerpt

AIMS: The ultimate cause of heart failure (HF) is not known to date. The cytoskeletal protein desmin is differentially modified and forms amyloid-like oligomers in HF. We postulated that desmin post-translational modifications (PTMs) could drive aberrant desmin aggregation in HF. Therefore, we identified these PTMs and investigated their impact on desmin amyloidogenicity in human and experimental HF. METHODS AND...

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Identifiers

PMID: 24413773
DOI: 10.1093/cvr/cvu003
PMCID: PMC3958618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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