Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aggregate-prone desmin mutations impair mitochondrial calcium uptake in primary myotubes.

Cell calcium - 1 Oct 2014

Smolina Natalia, Bruton Joseph, Sjoberg Gunnar, Kostareva Anna, Sejersen Thomas

Abstract excerpt

Desmin, being a major intermediate filament of mature muscle cell, interacts with mitochondria within the cell and participates in mitochondria proper localization. The goal of the present study was to assess the effect of aggregate-prone and non-aggregate-prone desmin mutations on mitochondrial calcium uptake. Primary murine satellite cells were transduced with lentiviruses carrying desmin in wild type or mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Cells, Cultured
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Desmin

Share to Heterocyclic Compounds, 3-Ring

Share to Mice, Inbred C57BL

Share to Mitochondria

Share to Muscle Fibers, Skeletal

Source

Identifiers

PMID: 25171807
DOI: 10.1016/j.ceca.2014.08.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aggregate-prone desmin mutations impair mitochondrial calcium uptake in primary myotubes.PMID 25171807Read ↗

Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties.Semantic proximity Read ↗

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.Semantic proximity Read ↗

Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue.Semantic proximity Read ↗

Desminopathies: pathology and mechanisms.Semantic proximity Read ↗

Desmin related disease: a matter of cell survival failure.Semantic proximity Read ↗

Desminopathies in muscle disease.Semantic proximity Read ↗

Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria.Semantic proximity Read ↗

Pathophysiological mechanisms of cardiomyopathies induced by desmin gene variants located in the C-Terminus of segment 2B.Semantic proximity Read ↗

Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages.Semantic proximity Read ↗

Desmin mutations impact the autophagy flux in C2C12 cell in mutation-specific manner.Semantic proximity Read ↗

On noxious desmin: functional effects of a novel heterozygous desmin insertion mutation on the extrasarcomeric desmin cytoskeleton and mitochondria.Semantic proximity Read ↗

Cardiomyopathy-Associated Mutations in a Hotspot Region at the C-Terminal Part of Desmin Coil-2 Domain Impair the Intermediate Filament Assembly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.