Decreased Prefrontal Activation during Matrix Reasoning in Predementia Progranulin Mutation Carriers.

Abstract excerpt

We tested the potential of task-based functional neuroimaging as a biomarker of emerging prefrontal brain changes in progranulin (GRN) mutations carriers. Five GRN mutation carriers free of frontotemporal dementia (FTD) and 11 non-carriers from families with FTD-GRN underwent functional MRI while solving matrix-reasoning problems. Mutation carriers displayed slower responses for more difficult problems and lower...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biomarkers
• Share to Frontotemporal Dementia