Article
ACE phenotyping in Gaucher disease.
Molecular genetics and metabolism - 1 Apr 2018
Danilov Sergei M, Tikhomirova Victoria E, Metzger Roman, Naperova Irina A, Bukina Tatiana M, Goker-Alpan Ozlem, Tayebi Nahid, Gayfullin Nurshat M, Schwartz David E, Samokhodskaya Larisa M, Kost Olga A, Sidransky Ellen
Abstract excerpt
BACKGROUND: Gaucher disease is characterized by the activation of splenic and hepatic macrophages, accompanied by dramatically increased levels of angiotensin-converting enzyme (ACE). To evaluate the source of the elevated blood ACE, we performed complete ACE phenotyping using blood, spleen and liver samples from patients with Gaucher disease and controls. METHODS: ACE phenotyping included 1) immunohistochemical...
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