Article
ACE phenotyping in human heart.
PloS one - 1 Jan 2017
Tikhomirova Victoria E, Kost Olga A, Kryukova Olga V, Golukhova Elena Z, Bulaeva Naida I, Zholbaeva Aigerim Z, Bokeria Leo A, Garcia Joe G N, Danilov Sergei M
Abstract excerpt
AIMS: Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, is expressed as a type-1 membrane glycoprotein on the surface of different cells, including endothelial cells of the heart. We hypothesized that the local conformation and, therefore, the properties of heart ACE could differ from lung ACE due to different...
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