Article
A novel variant associated with HDL-C levels by modifying DAGLB expression levels: An annotation-based genome-wide association study.
European journal of human genetics : EJHG - 1 Jun 2018
Zhou Dan, Zhang Dandan, Sun Xiaohui, Li Zhiqiang, Ni Yaqin, Shan Zhongyan, Li Hong, Liu Chengguo, Zhang Shuai, Liu Yi, Zheng Ruizhi, Pan Feixia, Zhu Yimin, Shi Yongyong, Lai Maode
Abstract excerpt
Although numbers of genome-wide association studies (GWAS) have been performed for serum lipid levels, limited heritability has been explained. Studies showed that combining data from GWAS and expression quantitative trait loci (eQTLs) signals can both enhance the discovery of trait-associated SNPs and gain a better understanding of the mechanism. We performed an annotation-based, multistage genome-wide screening...
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