Article
A novel AST2 mutation generated upon whole-genome transformation of Saccharomyces cerevisiae confers high tolerance to 5-Hydroxymethylfurfural (HMF) and other inhibitors.
PLoS genetics - 1 Oct 2021
Vanmarcke Gert, Deparis Quinten, Vanthienen Ward, Peetermans Arne, Foulquié-Moreno Maria R, Thevelein Johan M
Abstract excerpt
Development of cell factories for conversion of lignocellulosic biomass hydrolysates into biofuels or bio-based chemicals faces major challenges, including the presence of inhibitory chemicals derived from biomass hydrolysis or pretreatment. Extensive screening of 2526 Saccharomyces cerevisiae strains and 17 non-conventional yeast species identified a Candida glabrata strain as the most 5-hydroxymethylfurfural...
Topics
- Fermentation
- Furaldehyde
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transformation, Genetic
- Bioreactors