Article
SnapShot: TP53 status and macrophages infiltration in TCGA-analyzed tumors.
International immunopharmacology - 1 Sept 2020
El-Arabey Amr Ahmed, Abdalla Mohnad, Abd-Allah Adel Rashad
Abstract excerpt
The infiltration of immune cells is a hallmark of most forms of malignancy. It is well known that in Tumor Microenvironment (TME), monocytes undergo reprogramming process to differentiate into Tumor Associated Macrophages (TAMs) (M2 macrophages). Interestingly, this reprogramming process depends on signals provided by tumors. Hence, tumors from several tissues are infiltrated by functionally distinct TAMs...
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