Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data.

doi:10.1200/JCO.2017.74.8301

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Article

Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2018

Zardavas Dimitrios, Te Marvelde Luc, Milne Roger L, Fumagalli Debora, Fountzilas George, Kotoula Vassiliki, Razis Evangelia, Papaxoinis George, Joensuu Heikki, Moynahan Mary Ellen, Hennessy Bryan T, Bieche Ivan, Saal Lao H, Stal Olle, Iacopetta Barry, Jensen Jeanette Dupont, O'Toole Sandra, Lopez-Knowles Elena, Barbaraeschi Mattia, Noguchi Shinzaburo, Azim Hatem A, Lerma Enrique, Bachelot Thomas, Wang Qing, Perez-Tenorio Gizeh, Can de Velde Cornelis J H, Rea Daniel W, Sabine Vicky, Bartlett John M S, Sotiriou Christos, Michiels Stefan, Loi Sherene

Abstract excerpt

Purpose Phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA) mutations are frequently observed in primary breast cancer. We evaluated their prognostic relevance by performing a pooled analysis of individual patient data. Patients and Methods Associations between PIK3CA status and clinicopathologic characteristics were tested by applying Cox regression models adjusted for age, tumor...

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PMID: 29470143
DOI: 10.1200/JCO.2017.74.8301

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