Article
A Brief Critique of the TATES Procedure.
Behavior genetics - 1 Mar 2018
Aliev Fazil, Salvatore Jessica E, Agrawal Arpana, Almasy Laura, Chan Grace, Edenberg Howard J, Hesselbrock Victor, Kuperman Samuel, Meyers Jacquelyn, Dick Danielle M
Abstract excerpt
The Trait-based test that uses the Extended Simes procedure (TATES) was developed as a method for conducting multivariate GWAS for correlated phenotypes whose underlying genetic architecture is complex. In this paper, we provide a brief methodological critique of the TATES method using simulated examples and a mathematical proof. Our simulated examples using correlated phenotypes show that the Type I error rate...
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