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Article

A novel FcεRIβ‐chain truncation regulates human mast cell proliferation and survival

16 Jun 2010

Abstract excerpt

Mast cells contribute to allergy through IgE-dependent activation via the high-affinity IgE receptor FcεRI. The role of the FcεRIβ chain (MS4A2) in mast cell function is not understood fully, although it serves to amplify FcεRI-dependent signaling. We demonstrate the expression of a novel MS4A2 truncation lacking exon 3 in human mast cells termed MS4A2(trunc). MS4A2(trunc) gene expression was regulated negatively...

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PMID: 20554927
DOI: 10.1096/fj.10-158378

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