Article
Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice.
Scientific reports - 20 Feb 2018
Orriss Isabel R, Lanham Stuart, Savery Dawn, Greene Nicholas D E, Stanier Philip, Oreffo Richard, Copp Andrew J, Galea Gabriel L
Abstract excerpt
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is poorly understood. Here, we first confirmed that core Wnt/PCP components are expressed in osteoblasts and osteoclasts in vitro. In vivo, we performed detailed µCT...
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