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Article

Large-scale mouse mutagenesis identifies novel genes affecting vertebral anatomy.

Mammalian genome : official journal of the International Mammalian Genome Society - 5 Feb 2026

Ibarra-Soria Ximena, Webb Elizabeth, Mulley John F

Abstract excerpt

We analyzed the International Mouse Phenotyping Consortium (IMPC) release 19 set of 8,539 phenotyped whole-gene knockouts to identify 204 genes that alter vertebral anatomy and development. These genes are broadly grouped into six categories based on their phenotype: "vertebral number" (22 genes); "vertebral processes" (35 genes); "spine shape" (16 genes); "tail morphology" (73 genes); "vertebral form" (62...

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Identifiers

PMID: 41644829
DOI: 10.1007/s00335-025-10189-x
PMCID: PMC12876460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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