Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.

doi:10.1073/pnas.2310283121

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Article

Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2024

Feng Xin, Ye Yongyu, Zhang Jianan, Zhang Yuanqiang, Zhao Sen, Mak Judith C W, Otomo Nao, Zhao Zhengye, Niu Yuchen, Yonezawa Yoshiro, Li Guozhuang, Lin Mao, Li Xiaoxin, Cheung Prudence Wing Hang, Xu Kexin, Takeda Kazuki, Wang Shengru, Xie Junjie, Kotani Toshiaki, Choi Vanessa N T, Song You-Qiang, Yang Yang, Luk Keith Dip Kei, Lee Kin Shing, Li Ziquan, Li Pik Shan, Leung Connie Y H, Lin Xiaochen, Wang Xiaolu, Qiu Guixing, Watanabe Kota, Wu Zhihong, Posey Jennifer E, Ikegawa Shiro, Lupski James R, Cheung Jason Pui Yin, Zhang Terry Jianguo, Gao Bo, Wu Nan

Abstract excerpt

Congenital scoliosis (CS), affecting approximately 0.5 to 1 in 1,000 live births, is commonly caused by congenital vertebral malformations (CVMs) arising from aberrant somitogenesis or somite differentiation. While Wnt/ß-catenin signaling has been implicated in somite development, the function of Wnt/planar cell polarity (Wnt/PCP) signaling in this process remains unclear. Here, we investigated the role of Vangl1...

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PMID: 38669183
DOI: 10.1073/pnas.2310283121
PMCID: PMC11067467

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