Article
Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease.
Brain : a journal of neurology - 1 Apr 2018
Franzmeier Nicolai, Düzel Emrah, Jessen Frank, Buerger Katharina, Levin Johannes, Duering Marco, Dichgans Martin, Haass Christian, Suárez-Calvet Marc, Fagan Anne M, Paumier Katrina, Benzinger Tammie, Masters Colin L, Morris John C, Perneczky Robert, Janowitz Daniel, Catak Cihan, Wolfsgruber Steffen, Wagner Michael, Teipel Stefan, Kilimann Ingo, Ramirez Alfredo, Rossor Martin, Jucker Mathias, Chhatwal Jasmeer, Spottke Annika, Boecker Henning, Brosseron Frederic, Falkai Peter, Fliessbach Klaus, Heneka Michael T, Laske Christoph, Nestor Peter, Peters Oliver, Fuentes Manuel, Menne Felix, Priller Josef, Spruth Eike J, Franke Christiana, Schneider Anja, Kofler Barbara, Westerteicher Christine, Speck Oliver, Wiltfang Jens, Bartels Claudia, Araque Caballero Miguel Ángel, Metzger Coraline, Bittner Daniel, Weiner Michael, Lee Jae-Hong, Salloway Stephen, Danek Adrian, Goate Alison, Schofield Peter R, Bateman Randall J, Ewers Michael
Abstract excerpt
Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may support higher reserve capacity, i.e. relatively high cognitive performance at a given level of Alzheimer's pathology. Higher functional MRI-assessed functional connectivity of a hub in the left frontal cortex is a core candidate brain...
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