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Article

Dysregulation of NEUROG2 plays a key role in focal cortical dysplasia

21 Feb 2018

Abstract excerpt

OBJECTIVE: Focal cortical dysplasias (FCDs) are an important cause of drug-resistant epilepsy. In this work, we aimed to investigate whether abnormal gene regulation, mediated by microRNA, could be involved in FCD type II. METHODS: We used total RNA from the brain tissue of 16 patients with FCD type II and 28 controls. MicroRNA expression was initially assessed by microarray. Quantitative polymerase chain...

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PMID: 29461643
DOI: 10.1002/ana.25187

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