Article
Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation.
The Journal of biological chemistry - 1 Jun 2001
Fanton C P, McMahon M, Pieper R O
Abstract excerpt
Normal human fibroblasts have been shown to undergo a p16(Ink4a)-associated senescence-like growth arrest in response to sustained activation of the Ras/Raf/MEK/ERK pathway. We noted a similar p16(Ink4a)-associated, senescence-like arrest in normal human astrocytes in response to expression of a conditional form of Raf-1. While HPV16 E7-mediated functional inactivation of the p16(Ink4a)/pRb pathway in astrocytes...
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