Article
Update on Hereditary Colorectal Cancer: Improving the Clinical Utility of Multigene Panel Testing.
Clinical colorectal cancer - 1 Jun 2018
Lorans Marie, Dow Eryn, Macrae Finlay A, Winship Ingrid M, Buchanan Daniel D
Abstract excerpt
Colorectal cancer (CRC), one of the most common cancers, is a major public health issue globally, especially in Westernized countries. Up to 35% of CRCs are thought to be due to heritable factors, but currently only 5% to 10% of CRCs are attributable to high-risk mutations in known CRC susceptibility genes, predominantly the mismatch repair genes (Lynch syndrome) and adenomatous polyposis coli gene (APC; familial...
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