Germline Cancer Susceptibility Gene Testing in Unselected Patients With Colorectal Adenocarcinoma: A Multicenter Prospective Study.

doi:10.1016/j.cgh.2021.04.013

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Article

Germline Cancer Susceptibility Gene Testing in Unselected Patients With Colorectal Adenocarcinoma: A Multicenter Prospective Study.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2022

Uson Pedro L S, Riegert-Johnson Douglas, Boardman Lisa, Kisiel John, Mountjoy Luke, Patel Neej, Lizaola-Mayo Blanca, Borad Mitesh J, Ahn Daniel, Sonbol Mohamad B, Jones Jeremy, Leighton Jonathan A, Gurudu Suryakanth, Singh Harminder, Klint Margaret, Kunze Katie L, Golafshar Michael A, Esplin Ed D, Nussbaum Robert L, Stewart A Keith, Bekaii-Saab Tanio S, Jewel Samadder Niloy

Abstract excerpt

BACKGROUND & AIMS: Hereditary factors play a role in the development of colorectal cancer (CRC). Identification of germline predisposition can have implications on treatment and cancer prevention. This study aimed to determine the prevalence of pathogenic germline variants (PGVs) in CRC patients using a universal testing approach, association with clinical outcomes, and the uptake of family variant testing....

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PMID: 33857637
DOI: 10.1016/j.cgh.2021.04.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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