Article
The Role of Gut Microbiota and Environmental Factors in Type 1 Diabetes Pathogenesis.
Frontiers in endocrinology - 1 Jan 2020
Dedrick Sandra, Sundaresh Bharathi, Huang Qian, Brady Claudia, Yoo Tessa, Cronin Catherine, Rudnicki Caitlin, Flood Michael, Momeni Babak, Ludvigsson Johnny, Altindis Emrah
Abstract excerpt
Type 1 Diabetes (T1D) is regarded as an autoimmune disease characterized by insulin deficiency resulting from destruction of pancreatic β-cells. The incidence rates of T1D have increased worldwide. Over the past decades, progress has been made in understanding the complexity of the immune response and its role in T1D pathogenesis, however, the trigger of T1D autoimmunity remains unclear. The increasing incidence...
Topics
- Animals
- Diabetes Mellitus, Type 1
- Gastrointestinal Microbiome
- Genetic Predisposition to Disease
- Humans
- Immune System