Vitamin D pathway genetic variants are able to influence sofosbuvir and its main metabolite pharmacokinetics in HCV mono-infected patients.

doi:10.1016/j.meegid.2018.02.016

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Vitamin D pathway genetic variants are able to influence sofosbuvir and its main metabolite pharmacokinetics in HCV mono-infected patients.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2018

Cusato Jessica, De Nicolò Amedeo, Boglione Lucio, Favata Fabio, Ariaudo Alessandra, Mornese Pinna Simone, Carcieri Chiara, Guido Federica, Avataneo Valeria, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio

Abstract excerpt

Vitamin D levels and genetic variants were associated with drug outcome/toxicity and concentrations. The plasma exposure of GS-331007, the main sofosbuvir metabolite, has been related to SVR. We evaluated the impact of polymorphisms in genes (CYP27B1, CYP24A1, VDBP and VDR) related to vitamin D pathway on sofosbuvir and GS-331007 plasma levels in HCV mono-infected patients at one month of treatment. Polymorphisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Monitoring

Share to Pharmacogenetics

Share to Receptors, Calcitriol

Share to Sofosbuvir

Share to Vitamin D

Share to Vitamin D-Binding Protein

Share to Vitamin D3 24-Hydroxylase

Source

Open in PubMed

Identifiers

PMID: 29452294
DOI: 10.1016/j.meegid.2018.02.016

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vitamin D pathway genetic variants are able to influence sofosbuvir and its main metabolite pharmacokinetics in HCV mono-infected patients.PMID 29452294Read ↗

Vitamin D pathway gene variants and HCV-2/3 therapy outcomes.Semantic proximity Read ↗

Vitamin D pathway gene polymorphisms affecting daclatasvir plasma concentration at 2 weeks and 1 month of therapy.Semantic proximity Read ↗

Genetic polymorphisms of vitamin D pathway predict antiviral treatment outcome in slow responder naïve patients with chronic hepatitis C.Semantic proximity Read ↗

Vitamin D pathway gene polymorphisms and hepatocellular carcinoma in chronic hepatitis C-affected patients treated with new drugs.Semantic proximity Read ↗

Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients.Semantic proximity Read ↗

Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study.Semantic proximity Read ↗

Genetic variant of RXR involved in the vitamin D metabolic pathway was linked to HCV infection outcomes among a high-risk Chinese population.Semantic proximity Read ↗

Impact of vitamin D receptor and binding protein gene polymorphisms in clinical and laboratory data of HCV patients: Cross sectional study.Semantic proximity Read ↗

Association of Vitamin D Gene Polymorphisms With HCV Infection Outcome.Semantic proximity Read ↗

Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy.Semantic proximity Read ↗

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.