Article
Vitamin D pathway gene variants and HCV-2/3 therapy outcomes.
Antiviral therapy - 1 Jan 2015
Cusato Jessica, Allegra Sarah, Boglione Lucio, De Nicolò Amedeo, Baietto Lorena, Cariti Giuseppe, Di Perri Giovanni, D'Avolio Antonio
Abstract excerpt
BACKGROUND: The combination of ribavirin and pegylated interferon-α is considered the standard of care for HCV-2/3 genotypes. The immune system plays a key role in the achievement of a sustained virological response (SVR). Vitamin D seems to influence antiviral response in chronic hepatitis C and its pathway is controlled by polymorphic genes such as CYP27B1, CYP24A1 and VDR. In this study, we have investigated...
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