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Article

Exploring the deleterious SNPs in XRCC4 gene using computational approach and studying their association with breast cancer in the population of West India.

Gene - 20 May 2018

Singh Preety K, Mistry Kinnari N, Chiramana Haritha, Rank Dharamshi N, Joshi Chaitanya G

Abstract excerpt

Non-homologous end joining (NHEJ) pathway has pivotal role in repair of double-strand DNA breaks that may lead to carcinogenesis. XRCC4 is one of the essential proteins of this pathway and single-nucleotide polymorphisms (SNPs) of this gene are reported to be associated with cancer risks. In our study, we first used computational approaches to predict the damaging variants of XRCC4 gene. Tools predicted...

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Source

Identifiers

PMID: 29452234
DOI: 10.1016/j.gene.2018.02.040

Genes

XRCC4

Variants

rs79561451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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