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Article

Genetic evidence for an evolutionarily conserved role of IL-7 signaling in T cell development of zebrafish.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2011

Iwanami Norimasa, Mateos Fernando, Hess Isabell, Riffel Nico, Soza-Ried Cristian, Schorpp Michael, Boehm Thomas

Abstract excerpt

In mammals, the cytokine IL-7 is a key regulator of various aspects of lymphocyte differentiation and homeostasis. Because of the difficulty of identifying cytokine homologs in lower vertebrates and the paucity of assay systems and reagents, the degree of functional conservation of cytokine signaling pathways, particularly those pertaining to lymphocyte development, is unclear. In this article, we report on the...

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Share to Evolution, Molecular
Share to Interleukin-7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Specificity

Share to Receptors, Interleukin-7

Share to Signal Transduction

Share to T-Lymphocytes

Share to Thymus Gland

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Source

Identifiers

PMID: 21562163
DOI: 10.4049/jimmunol.1003907

Genes

JAK1
JAK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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