Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children.

PloS one - 1 Jan 2018

Arama Charles, Diarra Issa, Kouriba Bourèma, Sirois Francine, Fedoryak Olesya, Thera Mahamadou A, Coulibaly Drissa, Lyke Kirsten E, Plowe Christopher V, Chrétien Michel, Doumbo Ogobara K, Mbikay Majambu

Abstract excerpt

AIM: Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a hepatic secretory protein which promotes the degradation of low-density lipoprotein receptors leading to reduced hepatic uptake of plasma cholesterol. Non-synonymous single-nucleotide polymorphisms in its gene have been linked to hypo- or hyper- cholesterolemia, depending on whether they decrease or increase PCSK9 activity, respectively. Since the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dried Blood Spot Testing
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Malaria

Share to Odds Ratio

Share to Proprotein Convertase 9

Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 29447211
DOI: 10.1371/journal.pone.0192850
PMCID: PMC5813955

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Malaria severity: Possible influence of the E670G PCSK9 polymorphism: A preliminary case-control study in Malian children.PMID 29447211Read ↗

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.Semantic proximity Read ↗

Toll-like receptor 9 and 4 gene polymorphisms in susceptibility and severity of malaria: a meta-analysis of genetic association studies.Semantic proximity Read ↗

A meta-analysis of the endothelial protein C receptor rs867186 genotype in malariaSemantic proximity Read ↗

Candidate polymorphisms and severe malaria in a Malian population.Semantic proximity Read ↗

Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria.Semantic proximity Read ↗

TLR9 polymorphisms in African populations: no association with severe malaria, but evidence of cis-variants acting on gene expression.Semantic proximity Read ↗

Toll-like receptor (TLR4) Asp299Gly and Thr399Ile polymorphisms in relation to clinical falciparum malaria among Nigerian children: a multisite cross-sectional immunogenetic study in LagosSemantic proximity Read ↗

Glucose-6-phosphate dehydrogenase status and severity of malarial anaemia in Nigerian children.Semantic proximity Read ↗

Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.Semantic proximity Read ↗

The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria.Semantic proximity Read ↗

Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.Semantic proximity Read ↗

CD36 T188G gene polymorphism and severe falciparum malaria in India.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.