Article
Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.
Malaria journal - 22 Jun 2009
Israelsson Elisabeth, Ekström Mattias, Nasr Amre, Dolo Amagana, Kearsley Susannah, Arambepola Gishanthi, Homann Manijeh Vafa, Maiga Bakary, Doumbo Ogobara K, Elghazali Gehad, Giha Hayder A, Troye-Blomberg Marita, Berzins Klavs, Tornvall Per
Abstract excerpt
BACKGROUND: C-reactive protein (CRP) is an acute phase protein that can activate various immune cells and bind to certain Fcgamma receptors. The latter may compete with the binding of IgG antibodies to these receptors and could thereby interfere with the antigen-specific immune response. Polymorphisms in the promoter region of the CRP gene have been strongly associated with the plasma concentration of CRP. The...
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