Article
Association of glutamine synthetase polymorphisms rs2296521, rs10911021 and rs12136955 with plasma ammonia concentration in valproic acid-treated Egyptian epilepsy patients.
Neurologia i neurochirurgia polska - 1 Jan 2024
El-Sayed Wessam, Hussein Abdelaziz M, Elmenshawi Ibrahim, Helal Ghada, Abbas Mohammed, Badawy Abdelnaser, Kiwan Nedaa A, El Tohamy Mahmoud, Awadalla Ghada, Abulseoud Osama A
Abstract excerpt
INTRODUCTION: The use of valproic acid (VPA) in the treatment of some psychiatric and neurological disorders such as bipolar disorder, migraines, and epilepsy is associated with hyperammonemia. However, the mechanism of this negative effect of VPA is unclear. In this study, we investigate gene glutamate-ammonia ligase (GLUL) polymorphisms for the glutamine synthetase (GS) enzyme, a key enzyme that catalyzes the...
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