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Neurodevelopmental clustering of gene expression identifies lipid metabolism genes associated with neuroprotection and neurodegeneration

2021-09-02

Abstract excerpt

APOE variants present the strongest association with sporadic Alzheimer’s Disease. APOE is also highly expressed during neurodevelopment in the Central Nervous System (CNS) and has been shown to be neuroprotective in infancy and gestation. We explored other lipid metabolism genes to determine whether they show a similar neurodevelopmental expression trajectory and are associated with neurodegeneration. APOE was by...

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Literature Corpus work
4f68a326-2490-5976-b6f3-8b4b0722238e
DOI
10.1101/2021.09.02.458277
Open publication

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Neurodevelopmental clustering of gene expression identifies lipid metabolism genes associated with neuroprotection and neurodegenerationDOI 10.1101/2021.09.02.458277
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