Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ALV Integration-Associated Hypomethylation at the TERT Promoter Locus.

Viruses - 10 Feb 2018

Lam Gary, Beemon Karen

Abstract excerpt

Avian leukosis virus (ALV) is a simple retrovirus that can induce B-cell lymphoma in chicken(s) and other birds by insertional mutagenesis. The promoter region of telomerase reverse transcriptase (TERT) has been identified as an important integration site for tumorigenesis. Tumors with TERT promoter integrations are associated with increased TERT expression. The mechanism of this activation is still under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Virus Integration
Share to Avian Leukosis Virus
Share to Chick Embryo

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CpG Islands

Share to Proviruses

Share to Telomerase

Share to Terminal Repeat Sequences

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 29439385
DOI: 10.3390/v10020074
PMCID: PMC5850381

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ALV Integration-Associated Hypomethylation at the TERT Promoter Locus.PMID 29439385Read ↗

The expression level of chicken telomerase reverse transcriptase in tumors induced by ALV-J is positively correlated with methylation and mutation of its promoter region.Semantic proximity Read ↗

The <i>MYC</i> , <i>TERT</i> , and <i>ZIC1</i> Genes Are Common Targets of Viral Integration and Transcriptional Deregulation in Avian Leukosis Virus Subgroup J-Induced Myeloid LeukosisSemantic proximity Read ↗

Distinct Patterns of HBV Integration and TERT Alterations between in Tumor and Non-Tumor Tissue in Patients with Hepatocellular Carcinoma.Semantic proximity Read ↗

MeDIP-Seq and RNA-Seq Releaved TGFB2 Associated with Disease Resistance to ALV-J Infection in ChickensSemantic proximity Read ↗

The DNA methylation status of the TERT promoter differs between subtypes of mature B-cell lymphomasSemantic proximity Read ↗

Role of DNA Methylation and CpG Sites in the Viral Telomerase RNA Promoter during Gallid Herpesvirus 2 Pathogenesis.Semantic proximity Read ↗

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity.Semantic proximity Read ↗

Temporal kinetics of Marek's disease herpesvirus: integration occurs early after infection in both B and T cells.Semantic proximity Read ↗

Integration Targeting by Avian Sarcoma-Leukosis Virus and Human Immunodeficiency Virus in the Chicken GenomeSemantic proximity Read ↗

An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines.Semantic proximity Read ↗

DNA hypomethylation leads to elevated mutation rates.Semantic proximity Read ↗

DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.