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Article

Allele-selective RUNX1 binding regulates P1 blood group status by transcriptional control of A4GALT.

Blood - 5 Apr 2018

Westman Julia S, Stenfelt Linn, Vidovic Karina, Möller Mattias, Hellberg Åsa, Kjellström Sven, Olsson Martin L

Abstract excerpt

P1 and Pk are glycosphingolipid antigens synthesized by the A4GALT-encoded α1,4-galactosyltransferase, using paragloboside and lactosylceramide as acceptor substrates, respectively. In addition to the compatibility aspects of these histo-blood group molecules, both constitute receptors for multiple microbes and toxins. Presence or absence of P1 antigen on erythrocytes determines the common P1 (P1+Pk+) and P2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29438961
DOI: 10.1182/blood-2017-08-803080

Genes

KLF1
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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