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Article

Single nucleotide polymorphisms in A4GALT spur extra products of the human Gb3/CD77 synthase and underlie the P1PK blood group system.

PloS one - 1 Jan 2018

Kaczmarek Radoslaw, Szymczak-Kulus Katarzyna, Bereźnicka Anna, Mikołajczyk Krzysztof, Duk Maria, Majorczyk Edyta, Krop-Watorek Anna, Klausa Elżbieta, Skowrońska Joanna, Michalewska Bogumiła, Brojer Ewa, Czerwinski Marcin

Abstract excerpt

Contrary to the mainstream blood group systems, P1PK continues to puzzle and generate controversies over its molecular background. The P1PK system comprises three glycosphingolipid antigens: Pk, P1 and NOR, all synthesised by a glycosyltransferase called Gb3/CD77 synthase. The Pk antigen is present in most individuals, whereas P1 frequency is lesser and varies regionally, thus underlying two common phenotypes:...

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Identifiers

PMID: 29709005
DOI: 10.1371/journal.pone.0196627
PMCID: PMC5927444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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